A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/07 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 39/193 (2006.01) A61K 39/23 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 37/04 (2006.01) C12N 7/02 (2006.01) C12N 7/06 (2006.01) C12N 15/82 (2006.01) C07K 14/32 (2006.01)
Patent
CA 2632245
The present invention relates generally to plant viruses, produced by plants, for use as vaccines and the like. More specifically, the present invention relates to simple inactivation methods, and plant virus particles thereby obtained. The invention described herein provides means and methods to produce a safe vaccine based on an epitope display of epitopes derived from a pathogenic agent on the surface of inactivated plant virus-like particles. This invention teaches inactivation of chimeric plant virus particles and integration of the inactivation step into the virus particle purification procedure. The inactivation method renders the virus incapable of infecting plants and the integrity of virus particles is retained.
La présente invention concerne de manière générale des virus de plante, produits par des plantes, à utiliser comme vaccins et autres. Plus spécifiquement, la présente invention concerne des procédés d'inactivation simples, et des particules de virus de plante ainsi obtenues. L'invention décrite ici propose des moyens et des procédés pour produire un vaccin sûr à base d'un affichage d'épitope des épitopes dérivés d'un agent pathogène sur la surface des particules de type virus de plante inactivé. La présente invention décrit l'inactivation de particules de virus de plante chimériques et l'intégration de l'étape d'inactivation dans le processus de purification des particules virales. Le procédé d'inactivation rend le virus incapable d'infecter les plantes et l'intégrité des particules virales est conservée.
Phelps Jamie P.
Rasochova Lada
Dow Global Technolgies Inc.
Pfenex Inc.
Sim & Mcburney
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