C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) C07D 317/28 (2006.01) C07D 317/72 (2006.01)
Patent
CA 2106679
Disclosed herein are novel platinum(II) complexe having a potent anti-tumor activity which are represented by formula (1), wherein R1 and R2, which may be the same or different, are a hydrogen atom or a C1-4 alkyl group, respectively, or joint- ly form a cycloalkane group together with the carbon atom attached thereto; two Xs jointly form a group represented by for- mula (a) or (b) wherein, R3 is a hydrogen atom or a methyl group; R4 and R5, which may be the same or different, are a hy- drogen atom or a C1-4 alkyl group, respectively, or jointly form a cyclobutane together with the carbon thereto; and the absolute configurations at the respective chiral centers in the 4,5-bis(aminomethyl)-1,3-dioxolane moiety are (4R, 5R) or (4S, 5S; processes for preparing the same; and their use for treating animal or human cancer. Further, disclosed herein are nov- el intermediates useful for the preparation of the platinum(II) complexes and processes for preparing said intermediates.
Cho Yong Baik
Gam Jongsik
Kim Dae-Kee
Kim Ganghyeok
Kim Hun Taek
Cassan Maclean
Sunkyong Industries Ltd.
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