Novel poly(ethylene oxide)-block-poly(ester) block copolymers

Details Novel poly(ethylene oxide)-block-poly(ester) block copolymers Novel poly(ethylene oxide)-block-poly(ester) block copolymers

C - Chemistry, Metallurgy

08

G

C08G 81/00 (2006.01) A61K 9/107 (2006.01) A61K 31/575 (2006.01) A61K 31/704 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/13 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) C07D 313/04 (2006.01) C08G 63/08 (2006.01) C08G 65/02 (2006.01) C08J 3/24 (2006.01) C08L 67/04 (2006.01) C08L 71/02 (2006.01)

Patent

CA 2646425

The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer.

La présente invention concerne des copolymères séquencés à base d'oxyde de polyéthylène et de bloc polyester de formation de micelles renfermant des groupes réactifs de bloc polyester. La biodégrabilité de ces copolymères et leurs biocompatibilités avec un grand nombre d'agents bioactifs les rendent aptes en tant que supports pour divers agents bioactifs. Les agents bioactifs, tels que l'ADN, l'ARN, oligonucéotide, protéine, peptide, médicament et analogues, peuvent être couplés aux groupes réactifs sur le bloc polyester du copolymère.

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