C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/18 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/27 (2006.01) A61K 31/381 (2006.01) A61K 31/395 (2006.01) A61P 35/00 (2006.01) C07C 211/52 (2006.01) C07C 211/54 (2006.01) C07C 233/36 (2006.01) C07C 233/39 (2006.01) C07C 233/40 (2006.01) C07C 233/62 (2006.01) C07C 233/78 (2006.01) C07C 235/34 (2006.01) C07C 235/50 (2006.01) C07C 237/10 (2006.01) C07C 237/22 (2006.01) C07C 237/42 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 275/28 (2006.01) C07C 279/14 (2006.01) C07C 311/0
Patent
CA 2318004
Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatiorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.
Bergstrom Donald E.
Burns Mark R.
O'day Christine L.
Vermeulin Nicolaas M.j.
Webb Heather K.
Fetherstonhaugh & Co.
Mediquest Therapeutics Inc.
Oridigm Corporation
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