Novel polyamine conjugated oligonucleotides

Details Novel polyamine conjugated oligonucleotides Novel polyamine conjugated oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07F 7/18 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2087731

2087731 9202531 PCTABS00010 Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides targeted at the tat region of HIV comprise certain preferred embodiments.

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