C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 51/43 (2006.01) A01N 37/02 (2006.01) A61K 47/44 (2006.01) C07C 67/56 (2006.01)
Patent
CA 2315853
Polyethoxylated castor oil with a low cation content are claimed, along with particular methods for achieving such low cation content polyethoxylated castor oil. One method of production of such a low cationic content polyethoxylated castor oil according to the invention is to pre-treat the polyethoxylated castor oil with a strong cationic exchange resin to remove a substantial portion of the cations present in an untreated polyethoxylated castor oil. The low cationic content polyethoxylated castor oil of the invention can then be utilized to prepare formulations of various agents which are found to be sensitive to the previously commercially available polyethoxylated castor oil (CREMOPHOR EL).
La présente invention concerne une huile de ricin polyéthoxylée à faible teneur en cations, et des procédés spécifiques permettant de fabriquer celle-ci. L'un de ces procédés consiste à pré-traiter l'huile de ricin polyéthoxylée avec une résine échangeuse de cations forte afin d'éliminer une partie importante des cations présents dans l'huile de ricin polyéthoxylée non traitée. On peut ensuite utiliser l'huile de ricin polyéthoxylée à faible teneur en cations de la présente invention pour préparer des formulations de divers agents sensibles à l'huile de ricin polyéthoxylée offerte sur le marché auparavant (CREMOPHOR EL?).
Butterhof Robert C.
Garber Mitchell
Hoyer Todd M.
Iyer Rupa
Nikolayev Aleksandr
Kirby Eades Gale Baker
Schein Pharmaceutical Inc.
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