Novel polymer supports for nucleic acid synthesis

Details Novel polymer supports for nucleic acid synthesis Novel polymer supports for nucleic acid synthesis

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01)

Patent

CA 2238865

The invention provides passivated organic polymer supports, processes for their preparation and processes for their use in oligonucleotide synthesis that allow for highly efficient solid phase synthesis of oligonucleotides. According to the invention, oligonucleotide synthesis is preferably carried out on an organic polymer support passivated by reaction with benzoic acid anhydride. The improved process reduces the amount of N-1 failure sequences.

L'invention concerne des supports en polymère organique passivés, ainsi que des procédés permettant leur préparation et leur utilisation pour la synthèse des acides nucléiques. Ils permettent de synthétiser des oligonucléotides en phase solide avec un rendement très élevé. Selon l'invention, on réalise de préférence la synthèse des oligonucléotides sur un support en polymère organique passivé par réaction avec l'anhydride d'acide benzoïque. Ce procédé amélioré diminue le nombre de perturbations au niveau de la séquence n-1.

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