C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2686457
Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphicforms and the use of said compositions in the treatment of patientssuffering from endothelin receptor mediated disorders, for example,cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.
L'invention concerne de nouvelles formes polymorphes de bosentan et leurs procédés de préparation. L'invention concerne également des compositions pharmaceutiques comprenant lesdites formes polymorphes et l'utilisation de ces compositions dans le traitement de patients souffrant de troubles médiés par le récepteur de l'endothéline, notamment les troubles cardiovasculaires tels que l'hypertension, l'hypertension pulmonaire, l'ischémie, le spasme vasculaire et l'angine de poitrine.
Bansode Prakash
Gaitonde Abhay
Manojkumar Bindu
Mekde Sandeep
Shinde Dattatraya
Generics [uk] Limited
Osler Hoskin & Harcourt Llp
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