C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/506 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2748218
The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2- morpholin- 4-yl-ethoxy)-pyrimidin-2- yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
La présente invention concerne le dihydrogénophosphate de 6-(1-méthyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-éthoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one, ses solvates et ses modifications cristallines. L'invention concerne également des procédés de préparation de ces modifications cristallines, ainsi que leur utilisation dans le traitement et/ou la prophylaxie d'états physiologiques et/ou pathophysiologiques qui sont causés, médiés et/ou propagés par l'inhibition, la régulation et/ou la modulation de la transduction du signal par des kinases, en particulier par l'inhibition des tyrosine kinases, par exemple d'états pathophysiologiques tels que le cancer.
Becker Axel
Donini Cristina
Dorsch Dieter
Kriegbaum Eva
Kuehn Clemens
Fetherstonhaugh & Co.
Merck Patent Gmbh
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