C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/425 (2006.01) A61P 3/10 (2006.01) A61P 9/12 (2006.01) C07D 277/34 (2006.01)
Patent
CA 2426117
This invention relates to novel polymorphic/pseudopolymorphic forms of 5-[4- [2[N-methyl-N-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate having formula (I). The invention also relates to a pharmaceutical composition comprising the novel polymorphic form or their mixture and a pharmaceutically acceptable carrier. The polymorphic forms of the present invention are more active, as antidiabetic agent, than the hitherto known 5-[4-[2-[N-(2-methyl-N- (2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate.
L'invention concerne des nouvelles formes polymorphes/pseudo-polymorphes de 5-[4-[2[N-méthyl-N-(2-pyridyl)amino]éthoxy]benzyl] thiazolidine-2,4-dione maléate de formule (I). L'invention concerne également une composition pharmaceutique renfermant les nouvelles formes polymorphes ou un mélange de celles-ci et un adjuvant acceptable sur le plan pharmaceutique. Les formes polymorphes selon l'invention sont plus actives, comme agent anti-diabétique, que le 5-[4-[2-[N-(2-méthyl-N-(2-pyridyl)amino]éthoxy]benzyl] thiazolidine-2,4-dione maléate connu jusqu'à présent.
Chebiyyam Prabhakar
Gaddam Om Reddy
Krishnamurthi Vyas
Mamillapalli Ramabhadra Sarma
Seella Vishnuvardhan Reddy
Dr. Reddy's Laboratories Limited
Dr. Reddy's Research Foundation
Marks & Clerk
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