Novel polymorphic forms of an antidiabetic agent: process...

C - Chemistry – Metallurgy – 07 – D

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C07D 265/38 (2006.01) A61K 31/535 (2006.01) A61K 31/538 (2006.01)

Patent

CA 2370401

This invention relates to novel polymorphic/pseudopolymorphic forms of arginine salt of 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid, having formula (I). The invention also relates to a pharmaceutical composition comprising the novel polymorphic form or their mixture and a pharmaceutically acceptable carrier. The polymorphic forms of the present invention are more active, as antidiabetic and hypolipidemic agent, than the novel 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid.

L'invention concerne de nouvelles formes polymorphes/pseudompolymorphes d'un sel arginine d'acide 3-[4-[2-(phénoxazine-10-yl)éthoxy]phényl]-2-éthoxypropanoïque de formule (I). L'invention concerne aussi une composition pharmaceutique comprenant les nouvelles formes polymorphes ou leur mélange et un support pharmaceutiquement acceptable. Les formes polymorphes sont plus actives comme agent antidiabétique et hypolipidémique que le nouvel acide 3-[4-[2-(phénoxazin-10-yl)éthoxy]phényl]-2-éthoxypropanoïque.

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