C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 46/10 (2006.01) C07C 50/32 (2006.01)
Patent
CA 2549871
Novel crystalline forms of anti Pneumocystis carinii compound (2-[4-(4- Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-~naphthoquinone) commonly known as Atovaquone and methods for producing the same is disclosed herein. This also provides pharmaceutical compositions comprising the said polymorphs of Atovaquone and method of treating Pneumocystis carinii pneumonia, the method comprising administering to a warm blooded animal an effective amount of a product-by-process composition of matter comprising polymorphic forms of Atovaquone.
L'invention porte sur de nouvelles formes cristallines d'un composé anti Pneumocystis carinii de formule 2-[4-(4-Chlorophényl)cyclohéxyl]-3-hydroxy-1,4--naphthoquinone, connu sous le nom d'Atovaquone, et sur ses méthodes d'obtention. L'invention porte également sur des préparations pharmaceutiques comprenant lesdits formes polymorphes d'Atovaquone, et sur des procédés de traitement la pneumonie à Pneumocystis carinii, consistant à administrer à un animal à sang chaud une quantité efficace d'une composition de substances obtenue par processus, comprenant lesdites formes polymorphes d'Atovaquone.
Mantripragada Narayana Rao
Patel Gautam Ramjibhai
Sathe Dhananjay Govind
Sawant Kamlesh Digambar
Tarur Venkatasubramanian Radhakrishnan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Usv Limited
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