Novel polymorphs of azabicyclohexane

Details Novel polymorphs of azabicyclohexane Novel polymorphs of azabicyclohexane

C - Chemistry, Metallurgy

07

D

C07D 209/52 (2006.01) A61K 31/403 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2619817

The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3, 4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms.

L'invention concerne des formes cristallines polymorphes de sels d'addition acide de (+)-1-(3, 4-dichlorophényl)-3-azabicyclo[3.1.0]hexane élaborées comme une forme polymorphe A, une forme polymorphe B et une forme polymorphe C, ladite forme polymorphe A étant plus stable sur le plan thermodynamique que les autres formes. Cette invention a aussi trait à des méthodes de préparation et d'utilisation de telles formes polymorphes et à des compositions pharmaceutiques contenant de telles formes polymorphes.

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