Novel polymorphs of lesopitron dichlorohydrate and its...

Details Novel polymorphs of lesopitron dichlorohydrate and its... Novel polymorphs of lesopitron dichlorohydrate and its...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2196425

The invention relates to the novel polymorphs (I and II) of dichlorohydrate of lesopitron, which are characterized by their X-ray diffractograms and infrared spectra. They are obtained by crystallization of lesopitron dichlorohydrate. It also relates to the forms I-hydrate and II-hydrate which are obtained from the corresponding polymorphs, and which have a water content from 3 to 6 % and from 1.5 to 2.5 %, respectively. Such products are useful in human medicine, essentially for their pharmacological activity on the central nervous system.

L'invention concerne les nouveaux polymorphes I et II de dichlorohydrate de lesopitron, caractérisés par leurs spectres infrarouges et diffractogrammes de rayons X. On les obtient par cristallisation du dichlorohydrate de lésopitron. L'invention concerne également les formes I-hydrate et II-hydrate, que l'on obtient à partir des polymorphes correspondants et qui possèdent une teneur en eau de 3 à 6 % et de 1,5 à 2,5 %, respectivement. De tels produits s'utilisent en médecine humaine essentiellement en raison de leur activité pharmacologique sur le système nerveux central.

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