C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2735084
The present invention relates to novel polymorphs of sunitinib free base designated form II and form III and to processes for their preparation. The invention also relates to their use as APIs and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising said novel polymorphs and salts, solvates and hydrates prepared according to the invention,and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer.
La présente invention concerne de nouveaux polymorphes de la base libre du sunitinib nommés forme II et forme III et leurs procédés de préparation. L'invention concerne également leur utilisation en tant qu'API et dans la préparation de diverses formes du sunitinib. En outre, l'invention concerne des compositions pharmaceutiques comprenant lesdits nouveaux polymorphes et sels, solvates et hydrates préparés selon l'invention, et les utilisations desdites compositions pharmaceutiques dans le traitement et/ou la prévention du cancer.
Bansode Prakash
Choudhari Bharati
Gore Vinayak
Hublikar Mahesh
Generics [uk] Limited
Osler Hoskin & Harcourt Llp
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