Novel polypeptide

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 1/11 (2006.01) C12N 5/14 (2006.01) C12N 5/16 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12P 19/28 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2421088

A novel polypeptide having a .beta.1,3-N-acetylglucosamine transferase activity; a sugar chain synthesizing agent containing this polypeptide; a process for producing a sugar chain and a complex carbohydrate by using this sugar chain synthesizing agent; a DNA encoding the above polypeptide; a process for producing the polypeptide; an antibody against the polypeptide; and a diagnostic method and a diagnostic for inflammation, cancer or cancer metastasis by using the above DNA or the above antibody. These substances are useful in the synthesis of useful sugar chains and diagnosis and treatment for inflammatory diseases, cancer or cancer metastasis.

L'invention concerne un nouveau polypeptide présentant une activité .beta.1,3-N-acétylglucosamine transférase ; un agent de synthèse de chaîne de sucre contenant ce polypeptide ; un procédé de fabrication d'une chaîne de sucre et d'un glucide complexe faisant intervenir cet agent de synthèse de chaîne de sucre ; une séquence d'ADN codant ledit polypeptide ; un procédé de fabrication dudit polypeptide ; un anticorps contre ledit polypeptide ; et, un procédé diagnostique destiné à diagnostiquer une inflammation, un cancer ou des métastases cancéreux au moyen de la séquence d'ADN ou dudit anticorps. Les composés selon l'invention servent à la synthèse de chaînes de sucre utiles, ainsi qu'au diagnostic et au traitement de maladies inflammatoires, de cancers ou de métastases cancéreux.

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