Novel polypeptide and anti-hiv agent containing the same

Details Novel polypeptide and anti-hiv agent containing the same Novel polypeptide and anti-hiv agent containing the same

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/04 (2006.01) A61P 31/18 (2006.01) C07K 14/435 (2006.01) C12N 9/99 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2421183

Polypeptides of Al-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an aromatic amino acid residue; A3, A4 and A6 are each a residue of arginine, lysine, ornithine, citrulline, or alanine; A5 is a residue of tyrosine, phenylalanine, alanine, naphthylalanine, or citrulline; A7 is a lysine or arginine residue whose carboxyl group may be converted into amido; and X is a residue of D-ornithylproline, prolyl-D- ornithine, D-lysylproline, or the like, with the proviso that any one of A1, A3, A4, A5, A6 and A7 is a residue of alanine or the like or that X is citrulline or the like).

Polypeptides de Al-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit-Cys-A7 ou leurs sels. Dans cette formule, A1 représente hydrogène ou un reste d'arginine, de lysine, d'ornithine, de citrulline, d'alanine ou analogue, A2 représente un reste d'acide aminé aromatique, A3, A4 et A6 représentent chacun un reste d'arginine, de lysine, d'ornithine, de citrulline ou d'alanine, A5 représente un reste de tyrosine, de phénylalanine, d'alanine, de naphtylalanine ou de citrulline, A7 est un reste de lysine ou d'arginine dont le groupe carboxyle peut être converti en amido et X représente un reste de D-ornithylproline, de prolyl-D-ornithine, de D-lysylproline ou analogue, à condition que l'un quelconque des éléments A1, A3, A4, A5, A6 et A7 représente un reste d'alanine ou analogue ou que X représente citrulline ou analogue.

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