C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 49/16 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2377791
A novel polypeptide; a DNA encoding the same; drugs containing the polypeptide or DNA; a method of screening a compound promoting or inhibiting the activity of the above polypeptide or its salt; a screening kit therefor; the compound or its salt obtained by this screening; drugs containing the above compound or its salt and the like. The above-described polypeptide and the DNA encoding the same are usable, for example, in diagnosing, treating and preventing bone and joint diseases and pathologic anagiogenesis. The polypeptide is also useful as a reagent for screening a compound promoting or inhibiting the activity of the polypeptide or its salt.
Cette invention se rapporte à un nouveau polypeptide; à un ADN codant ce polypeptide; à des médicaments contenant ce polypeptide ou cet ADN; à un procédé de criblage d'un composé favorisant ou inhibant l'activité de ce polypeptide ou à son sel; à un kit de criblage prévu à cet effet, au composé ou à son sel obtenu par ce criblage; à des médicaments contenant ce composé ou son sel et similaire. Ce polypeptide et l'ADN codant ce polypeptide sont utilisables, notamment, dans le diagnostic, le traitement et la prévention de maladies des os et des articulations et de l'angiogenèse pathologique. Ce polypeptide sert également de réactif pour le criblage d'un composé favorisant ou inhibant l'activité de ce polypeptide ou de son sel.
Itoh Yasuaki
Mogi Shinichi
Nishi Kazunori
Noguchi Yuko
Ogi Kazuhiro
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
Takeda Pharmaceutical Company Limited
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