Novel polypeptide ligands for toll-like receptor 2 (tlr2)

Details Novel polypeptide ligands for toll-like receptor 2 (tlr2) Novel polypeptide ligands for toll-like receptor 2 (tlr2)

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2596079

The present invention provides novel polypeptide ligands for Toll-like Receptor 2 (TLR2). Preferrably, the novel polypeptide ligands modulate TLR2 signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising the novel polypeptide TLR2 ligands and an antigen. The invention further provides methods of modulating TLR2 signaling using the polypeptide ligands or vaccines of the invention.

L'invention concerne de nouveaux ligands de polypeptides destinés à un récepteur de type Toll 2 (TLR2). De préférence, les nouveaux ligands de polypeptides modulent la signalisation du TLR2 et régulent ainsi la réponse immunitaire innée. L'invention concerne également des vaccins contenant ces nouveaux ligands de polypeptides TLR2 et un antigène. L'invention concerne enfin des procédés de modulation de la signalisation du TLR2 au moyen des ligands de polypeptides ou des vaccins de l'invention.

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