C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/31 (2006.01)
Patent
CA 2748522
The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus ('CHIPS'), the polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 2, or a fragment or variant thereof having a biological activity of CHIPS, wherein the fragment or variant retains amino acid substitutions K40E, D42V, N77H, K100R, K105R, N111K and/or G112A relative to the wildtype CHIPS protein of SEQ ID NO:1. In one embodiment, polypeptide consists of the amino acid sequence of SEQ ID NO: 2. Related aspects of the invention provide pharmaceutical compositions comprising a polypeptide of the invention, together with methods or making and using the same.
L'invention concerne un polypeptide présentant une activité biologique de la protéine inhibitrice des Chemotaxis du Staphylococcus aureus (CHIPS). Le polypeptide comprend ou est constitué de la séquence d'acides aminés de SEQ ID NO: 2, ou d'un fragment ou d'un variant de celle-ci, et présente une activité biologique de CHIPS, le fragment ou le variant retenant des substitutions d'acides aminés K40E, D42V, N77H, K100R, K105R, N111 K et/ou G112A relatives à la protéine CHIPS de type sauvage de la SEQ ID NO:1. Dans un mode de réalisation, le polypeptide est constitué de la séquence d'acides aminés de SEQ ID NO: 2. L'invention concerne des compositions pharmaceutiques comprenant le polypeptide de l'invention ainsi que des procédés de production ou d'utilisation de ce dernier.
Furebring Christina
Gustafsson Erika
Haraldsson Karin
Rosen Anna
Walse Bjoern
Alligator Bioscience Ab
Borden Ladner Gervais Llp
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