Novel polypeptides having endolysin activity and uses thereof

Details Novel polypeptides having endolysin activity and uses thereof Novel polypeptides having endolysin activity and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/01 (2006.01) C12N 9/36 (2006.01)

Patent

CA 2706600

The present invention provides isolated polypeptides comprising the amino acid sequence of SEQ ID NO:1, or a fragment, variant, derivative or fusion thereof which is capable of binding specifically to and/or lysing cells of Clostridium difficile, and means for producing the same, with the proviso that the fragment, variant, derivative or fusion is not a naturally occurring lysin of a bacteriophage of Clostridium difficile. The invention further provides methods for killing bacterial cells, such as cells of Clostridium difficile, and for diagnosing, treating and preventing diseases and conditions associated with infection of the same. The invention also provides diagnostic kits for use in such methods.

LA présente invention concerne des polypeptides isolés qui comportent la séquence d'acides aminés de la SEQ ID N° : 1, ou un fragment, un variant, un dérivé ou une fusion de celle-ci qui peut se lier de façon spécifique à et/ou lyser des cellules de Clostridium difficile, et des moyens permettant de produire ces polypeptides, à condition que le fragment, le variant, le dérivé ou la fusion ne soit pas une lysine de bactériophage de Clostridium difficile présente dans la nature. L'invention concerne en outre des procédés permettant de tuer des cellules bactériennes, telles que les cellules de Clostridium difficile, et de diagnostiquer, traiter et prévenir des maladies et des états associés à une infection de celles-ci. L'invention concerne également des kits diagnostiques destinés à être utilisés dans ces procédés.

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