C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2382859
The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis.
L'invention concerne de nouveaux polypeptides critiques pour l'angiogenèse et la vascularisation et des molécules d'acides nucléiques codant pour ces polypeptides. Font aussi l'objet de cette invention des vecteurs et des cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules chimériques de polypeptides comprenant les polypeptides de cette invention fusionnés avec des séquences polypeptidiques hétérologues, des anticorps se liant aux polypeptides de cette invention et des procédés d'obtention desdits polypeptides. Font en outre l'objet de cette invention des compositions et des procédés permettant de stimuler ou d'inhiber l'angiogenèse et/ou la néo- ou cardiovascularisation chez les mammifères, y compris les êtres humains. Les compositions pharmaceutiques utilisent des polypeptides ou antagonistes qui ont été identifiés pour une ou plusieurs de ces applications. Les troubles susceptibles d'être diagnostiqués, évités ou traités par ces compositions sont les traumatismes tels que les blessures, les différents cancers et les troubles des vaisseaux y compris l'athérosclérose.
Gerritsen Mary E.
Goddard Audrey
Grimaldi J. Christopher
Mehraban Fuad
Cassan Maclean
Curagen Corporation
Genentech Inc.
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