Novel polypeptides with a blood coagulation-inhibiting...

Details Novel polypeptides with a blood coagulation-inhibiting... Novel polypeptides with a blood coagulation-inhibiting...

C - Chemistry, Metallurgy

07

K

530/1, 167/103.0

C07K 14/815 (2006.01) A61K 38/58 (2006.01) C07K 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340102

The invention relates to the use of anticoagulants in the prophylaxis and the therapy of thromboembolic processes and to a polypeptide of the formula 1 2 3 4 5 6 7 8 9 10 11 12 13 14 H- (X) m -A-B-C-Tyr-Thr-Asp-Cys-F-Glu-Ser-Gly-Gln-Asn-Leu- 16 17 18 19 20 21 22 23 24 25 26 27 -Cys-Leu-Cys-Glu-Gly-Ser-Asn-Val Cys Gly J -Gly-Asn- 28 29 30 31 32 33 34 35 36 37 38 39 40 -Lys-Cys-Ile-Leu-Gly-Ser-Asp-Gly- D - G -Asn-Gln-Cys- 41 42 43 44 45 46 47 48 49 50 51 52 53 -Val-Thr-Gly-Glu-Gly-Thr-Pro-Lys-Pro-Gln-Ser-His-Asn- 54 55 56 57 58 59 60 61 62 63 64 65 -Asp-Gly-Asp-Phe-Glu- E -ILe-Pro-Glu-Glu-Tyr(R)- 1 - 66 -Gln-(Z)n OH in which R represents phenolic hyrdrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.

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