C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/62 (2006.01) A61K 31/045 (2006.01) A61K 31/075 (2006.01) A61K 31/23 (2006.01) C07C 35/34 (2006.01) C07C 43/196 (2006.01) C07C 69/007 (2006.01) C07C 69/013 (2006.01) C07C 69/03 (2006.01) C07C 69/52 (2006.01) C07D 309/12 (2006.01) C07F 5/04 (2006.01) C07F 7/08 (2006.01) C12N 1/14 (2006.01) C12P 7/02 (2006.01) C12P 17/06 (2006.01)
Patent
CA 2179068
The present invention relates to novel potassium chan- nel agonists which are useful in activating the calcium acti- vated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of general formula (II). In addition, a novel microbiological process for producing the claimed compounds is described.
La présente invention se rapporte à de nouveaux agonistes des canaux de potassium qui sont utilisés dans l'activation du canal de potassium Maxi-K activé par calcium dans les tissus mammaliens neuronaux et des muscles lisses. Les composés revendiqués sont représentés par la formule générale (II). L'invention se rapporte également à un nouveau procédé microbiologique de production des composés revendiqués.
Garcia Maria L.
Giacobbe Robert A.
Hensens Otto D.
Kaczorowski Gregory J.
Lee Seok H.
Goudreau Gage Dubuc
Merck & Co. Inc.
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