C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/54 (2006.01) A61K 31/423 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) C07D 263/56 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2727780
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
La présente invention concerne des composés utiles dans la modulation de l'activité de canal potassique dans les cellules, en particulier l'activité des canaux Kv1.3 trouvés dans les lymphocytes T. L'invention concerne également l'utilisation de ces composés dans le traitement ou la prévention de maladies auto-immunes et inflammatoires, y compris la sclérose en plaques, des compositions pharmaceutiques contenant ces composés et des procédés pour leur préparation.
Baell Jonathan Bayldon
Cooke Rachel Christine
Crossman Julia Stephanie
Flynn Bernard Luke
Gill Gurmit Singh
Bionomics Limited
Kirby Eades Gale Baker
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