C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 45/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2480427
It is intended to disclose a novel polypeptide; a polynucleotide encoding the above polypeptide; an expression vector containing the above polynucleotide; cells transfected with the above expression vector; a process for producing the above polypeptide; and a convenient screening method for obtaining a substance which is useful in treating cell injury or an inflammatory disease due to postischemic reperfusion. The above-described polypeptide is a potassium-dependent sodium-calcium exchanger expressed in peripheral leucocytes.
L'invention concerne un nouveau polypeptide, un polynucléotide codant pour le nouveau polypeptide, un vecteur d'expression contenant ledit polynucléotide, des cellules transfectées par ledit vecteur d'expression, un procédé de production dudit polypeptide, et une méthode de criblage adaptée permettant d'obtenir une substance servant à traiter une lésion cellulaire ou une maladie inflammatoire due à une reperfusion post-ischémique. Ledit polypeptide est un échangeur de sodium-calcium dépendant du potassium exprimé dans les leucocytes périphériques.
Mochizuki Shinobu
Nozawa Katsura
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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