C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 239/08 (2006.01) A61K 31/16 (2006.01) A61K 31/164 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/221 (2006.01) A61K 31/277 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) A61K 31/4453 (2006.01) C07C 233/05 (2006.01) C07C 233/06 (2006.01) C07C 233/07 (2006.01) C07C 233/15 (2006.01) C07C 233/25 (2006.01) C07C 233/36 (2006.01) C07C 233/43 (2006.01) C07C 233/54 (2006.01) C07C 233/65 (2006.01) C07C 233/92 (2006.01) C07C 237/42 (2006.01) C07C 247/16 (2006.01) C07C 255/42 (2006.01) C07C 25
Patent
CA 2120619
The present invention provides the compound having structure (I), wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R1 and R2 are different, R1 = R3-N-R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present inventtion provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
Breslow Ronald
Jursic Branko
Marks Paul A.
Rifkind Richard A.
Gowling Lafleur Henderson Llp
Sloan Kettering Institute For Cancer Research
Sloan-Kettering Institute For Cancer Research
The Trustees Of Columbia University In The City Of New York
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