Novel process

Details Novel process Novel process

C - Chemistry, Metallurgy

07

C

C07C 213/08 (2006.01) C07C 43/172 (2006.01) C07C 217/10 (2006.01)

Patent

CA 2625337

The present invention relates to processes for the preparation of 4- hydroxy- .alpha.' -[[[6-(4-phenylbutoxy)hexyl]amino]methyl]- 1,3-benzenedimethanol 1- hydroxy-2-naphthoate (salmeterol xinafoate) (Formula (12a)), the preparation of 4-hydroxy-.alpha.'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3- benzenedimethanol (salmeterol) (Formula (11)), the preparation of protected N- [6-(4-phenylbutoxy)hexyl]amine intermediates (Formula (7)), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (Formula (5)), shown below, wherein X is a leaving group and Pg is a protecting group.

La présente invention a trait à des procédés pour la préparation de 4- hydroxy-a' -[[[6-(4-phénylbutoxy)hexyl]amino]méthyl]- 1,3-benzénediméthanol 1-hydroxy-2-naphtoate (salméterol xinafoate) (Formule 12a)), la préparation de 4-hydroxy-a'-[[[6-(4-phénylbutoxy)hexyl]amino]méthyl]-1,3-benzénediméthanol (salméterol) (Formule (11)), la préparation d'intermédiaires de N-[6-(4-phénylbutoxy)hexyl]amine (Formule (7)) protégés, et la préparation d'intermédiaires de (4-phénylbutoxy)hexane (Formule (5)) substitués en position 6, dans laquelle: X est un groupe partant et Pg est un groupe protecteur.

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