Novel process for manufacturing paroxetine solid dispersions

Details Novel process for manufacturing paroxetine solid dispersions Novel process for manufacturing paroxetine solid dispersions

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/4525 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2295752

Solid dispersions of poorly soluble drugs are disclosed which are prepared using a solvent or fusion process. Such dispersions are manufactured with the free base of the drug, specifically paroxetine free base, an oil, allowing for a low temperature for the fusion process, decreased organic solvent volumes for the solvent process and the formation of a paroxetine salt during the solid dispersion manufacture process.

La présente invention concerne des dispersions solides de médicaments à faible solubilité préparés au moyen d'un solvant ou d'un processus de fusion. Ces dispersions sont fabriquées à partir de la base libre du médicament, notamment la base libre de la paroxétine, d'une huile, tout en permettant l'utilisation d'une basse température dans le processus de fusion, ou de faibles volumes de solvant organique dans le processus avec solvant, la formation d'un sel de paroxétine s'effectuant pendant le procédé de fabrication de la dispersion solide.

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