Novel process for the preparation of amino acid derivatives

Details Novel process for the preparation of amino acid derivatives Novel process for the preparation of amino acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 231/20 (2006.01) C07C 237/06 (2006.01) C07C 237/22 (2006.01) C07C 237/52 (2006.01)

Patent

CA 2739741

The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3- methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).

La présente demande de brevet concerne un procédé inédit de fabrication de dérivés d'acides aminés. La présente demande concerne, en particulier, un procédé amélioré de fabrication de Lacosamide (LCM), ou (R)-2-acétamido-N-benzyl-3-méthoxypropion-amide, qui peut être utilisé en tant que médicament anticonvulsif. Selon un aspect particulier, la présente invention concerne un procédé de fabrication de (R)-2-acétamido-N-benzyl-3-méthoxypropion-amide (I) optiquement enrichi, comprenant la résolution du 2-acétamido-N-benzyl-3-méthoxypropion-amide (II).

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