Novel processes for the preparation of substituted propenone...

Details Novel processes for the preparation of substituted propenone... Novel processes for the preparation of substituted propenone...

C - Chemistry, Metallurgy

07

D

C07D 307/46 (2006.01) A61K 31/4196 (2006.01) A61P 31/18 (2006.01) C07D 249/10 (2006.01) C07D 307/58 (2006.01) C07D 307/68 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2376043

Industrial and commercial processes for the preparation of 2-acyl-5- benzylfuran derivatives, 1,2,4-triazole-3- carboxylic acid ester derivatives or propenone derivatives having an anti-HIV activity; and useful crystals of the derivatives. A...deblocking: (III-2), (IV-10), (VI-1), wherein R1, R2 and R4 are each independently hydrogen or the like; A is CR6 or N; R6 is hydrogen or the like; Q is a protecting group; and L is a leaving group.

Cette invention a trait à des procédés industriels et commerciaux de préparation de dérivés de 2-acyl-5-benzylfuranne, de dérivés d'ester d'acide carboxylique 1,2,4-triazol-3 ou de dérivés de propénone dotés d'une action anti-VIH. Elle concerne également des cristaux de ces dérivés s'avérant des plus utiles. A dégroupage: (III-2), (IV-10), (VI-1), dans laquelle, R?1¿, R?2¿ et R?4¿ représentent, chacun de manière indépendante, un hydrogène ou analogue, A représente CR?6¿ ou N, R?6¿ représente un hydrogène ou analogue, Q représente un groupe protecteur et L un groupe partant.

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