Novel processes to form-i of olanzapine

Details Novel processes to form-i of olanzapine Novel processes to form-i of olanzapine

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01)

Patent

CA 2591644

A process for obtaining crystalline Form-I olanzapine comprising the following: a) dissolving crude olanzapine in a solvent to form a solution, b) optionally drying by azeotropic distillation to remove water, c) precipitating by adding the solution of step (a) to an antisolvent, and d) isolating the precipitated crystalline Form-I olanzapine by filtration and drying at ambient temperature.

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