Novel prolines as antimicrobial agents

Details Novel prolines as antimicrobial agents Novel prolines as antimicrobial agents

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4184 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/437 (2006.01) A61K 31/52 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 473/34 (2006.01)

Patent

CA 2372176

Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of general formula (I), wherein Ar is aryl and heteroaryl; L is -C(O)N(Q)CH2-, or -CR10R11OCR12R13-; Q is hydrido, -(CH2)mCO2H and -(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.

La présente invention concerne des inhibiteurs de synthétase d'acide ribonucléique de transfert (ARNt), des sels et des compositions acceptable sur le plan pharmaceutique de ces produits de formule générale (I), dans laquelle Ar est un groupe aryle et hétéroaryle, L est un groupe -C(O)N(Q)CH¿2?-, ou CR?10¿R?11¿OCR?12¿R?13¿-, Q est un groupe dihydro, -(CH¿2?)¿m?CO¿2?H et -(CH¿2?)¿m?CO¿2?CH¿3?, avec m prenant les valeurs 1, 2, 3 et 4, et R?1¿, R?2¿, R?9¿, R?10¿, R?11¿, R?12¿, et R?13¿ sont des groupes hydrido ou des alkyles inférieurs. Dans cette formule, Het est un groupe hétérocyclique. Ces inhibiteurs conviennent à l'usage comme agents antimicrobiens.

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