C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61P 13/12 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2480892
It is intended to disclose a promoter of protease MDTS9 which is useful as a tool in screening a remedy and/or a preventive for chronic kidney failure, is derived by TGF-.beta., participates in the metabolism of extracellular matrix, and shows an elevated gene expression dose in a model animal of kidney failure; and a method of screening a remedy and/or a preventive for chronic kidney failure which comprises selecting an inhibitor for the above promoter.
La présente invention vise à fournir un promoteur de la protéase MDTS9 utile en tant qu'outil dans le criblage d'un agent thérapeutique et/ou prophylactique de l'insuffisance rénale chronique, dérivé du facteur de croissance transformant bêta (TGF-.beta.), impliqué dans le métabolisme de la matrice extracellulaire, et présentant un dosage élevé d'expression génétique dans un modèle animal d'insuffisance rénale. L'invention a également trait à un procédé de criblage d'agent thérapeutique et/ou prophylactique comportant la sélection d'un inhibiteur dudit promoteur.
Abe Kunitake
Takeda Masayoshi
Yamaji Noboru
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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