C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 48/00 (2006.01) C12N 15/12 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2317934
The invention is directed to novel promoter elements for the persistent expression of an operably linked transgene. In one aspect the promoter elements are derived from the cytomegalovirus intermediate early promoter (CMV). In particular embodiments of the invention, an adenoviral vector or plasmid comprising CMV-derived promoter elements are used to achieve presistent expression of a transgene in a target cell. The invention is also directed to enhancer elements which effectuate increased expression of a transgene operably linked to CMV-derived promoter elements. In one aspect, the enhancer elements are derived from the human albumin gene.
Cette invention concerne de nouveaux éléments de promoteur qui assurent l'expression durable d'un transgène lié de manière fonctionnelle. Selon un aspect de l'invention, les éléments de promoteur proviennent du promoteur précoce d'intermédiaire de cytomégalovirus (CMV). Dans des formes de réalisation particulières de l'invention, on utilise un vecteur adénoviral ou un plasmide comprenant des éléments de promoteur dérivés de CMV pour assurer l'expression durable d'un transgène dans une cellule cible. Cette invention concerne également des éléments amplificateurs qui effectuent l'expression accrue d'un transgène lié de manière fonctionnelle à des éléments de promoteur dérivés de CMV. Selon un aspect de l'invention, les éléments amplificateurs proviennent du gène humain de l'albumine.
Armentano Donna
Marshall John
Yew Nelson
Genzyme Corporation
Gowling Lafleur Henderson Llp
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