Novel propionic acid derivative

Details Novel propionic acid derivative Novel propionic acid derivative

C - Chemistry, Metallurgy

07

C

C07C 271/16 (2006.01) A61K 31/216 (2006.01) A61K 31/275 (2006.01) A61K 31/36 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) C07B 57/00 (2006.01) C07C 269/04 (2006.01) C07C 271/48 (2006.01) C07C 273/18 (2006.01) C07C 275/10 (2006.01) C07C 275/24 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/32 (2006.01) C07C 275/42 (2006.01) C07D 317/66 (2006.01)

Patent

CA 2477205

A compound represented by the following formula (1): (1) (wherein R1~ represents C~1-12 alkyl, phenyl, 1-naphthyl, etc.; R2~ represents C~2-12 alkyl; (R3~)~b represent zero to four substituents, e.g., halogeno; R4~ represents lower alkyl; R5~ represents hydrogen or lower alkyl; n is an integer of 2 to 4; and X represents -NH- or -O-) or a salt of the compound. The compound or salt is highly effective in lowering blood sugar, lipid, and total cholesterol and is useful as an active ingredient for medicines for the prevention of and/or treatments for diseases such as diabetes and hyperlipemia.

La présente invention concerne un composé représenté par la formule (1) suivante : (dans laquelle R1 représente alkyke C1-12, phényle, 1-naphthyle, etc. ; R2 représente alkyle C2-12 ; (R3)b représente de zéro à quatre substituants, par ex., halogéno ; R4 représente alkyle inférieur ; R5 représente hydrogène ou alkyle inférieur ; n est un entier de 2 à 4 ; et X représente NH- ou O-), ou un sel dudit composé. Le composé ou sel de l'invention est d'une grande efficacité pour réduire le niveau de sucre sanguin, de lipides et de cholestérol total et il est utilisé comme ingrédient actif dans des médicaments destinés à la prévention et/ou au traitement de maladies telles que le diabète et l'hyperlipidémie.

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