Novel prostaglandin i2 derivative

Details Novel prostaglandin i2 derivative Novel prostaglandin i2 derivative

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/5585 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2736039

Disclosed is a novel prostaglandin 12 derivative which is different from known PGI2 analogs, or a pharmaceutically acceptable salt thereof. More specifically disclosed is a 7,7- difluoro-PGI2 derivative (formula (1)), particularly wherein R1 and R2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1 - 3, and R3 is a hydrogen atom, an alkyl group having a carbon number of 1 - 4, an alkoxyalkyl group, an aryl group, a halogen atom or a haloalkyl group. Image

La présente invention concerne un nouveau dérivé de prostaglandine I2 qui est différent de composés PGI2 connus, ou un sel pharmaceutiquement acceptable du dérivé de prostaglandine I2. La présente invention concerne plus spécifiquement un dérivé de 7,7-difluoro-PGI2 (formule (1)), en particulier dans lequel R1 et R2 représentent indépendamment un atome dhydrogène ou un groupe alkyle linéaire ayant de 1 à 3 atomes de carbone, et R3 représente un atome dhydrogène, un groupe alkyle ayant de 1 à 4 atomes de carbone, un groupe alcoxyalkyle, un groupe aryle, un atome dhalogène, ou un groupe alkyle halogéné.

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