Novel protein and dna thereof

Details Novel protein and dna thereof Novel protein and dna thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2355968

A novel protein having an Na+-HCO3- cotransporter activity; a DNA encoding the same, etc. This protein and the DNA encoding the same are usable: (1) in acquiring an antibody and an antiserum; (2) in constructing a recombinant protein expression system; (3) in developing a system for assaying the activity of Na+-HCO3- cotransporter and screening compounds candidates for a drug by using the above expression system; (4) in drug-designing based on the three-dimensional structure of the Na+-HCO3- cotransporter protein; (5) as reagents for constructing probes and PCR primers in gene diagnosis; (6) in constructing a transgenic animal; and (7) as drugs such as gene preventives and/or remedies.

La présente invention concerne une protéine présentant une activité co-transporteuse de Na?+¿-HCO¿3??-¿, ainsi que l'ADN codant pour cette protéine. Cette protéine et cet ADN qui la code sont utiles (1) dans l'acquisition d'un anticorps et d'un antisérum, (2) dans la construction d'un système d'expression de protéine recombinée, (3) dans le développement d'un système de test d'activité co-transporteuse de Na?+¿-HCO¿3??-¿ et de criblage de composés potentiels pour un médicament à l'aide du système d'expression ci-dessus, (4) dans la conception de médicament basée sur la structure tridimensionnelle de la protéine co-transporteuse, (5) comme réactifs afin de construire des sondes et des amorces de PCR pour le diagnostic de gènes, (6) dans la construction d'un animal transgénique, et (7) comme médicaments préventifs et/ou remèdes en génétique.

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