C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/02 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2349869
A protein which is expressed particularly in the brain, has a PDZ domain and/or a WW domain and shows an affinity with, in particular, activin receptor and/or activin intracellular signal transducer molecule, its peptide fragment or a salt thereof which are useful in determining a binding protein capable of binding to the above protein and screening a compound inhibiting or promoting the binding of the binding protein to the above-described protein, etc.
L'invention concerne une protéine exprimée particulièrement dans le cerveau, qui comprend un domaine PDZ et/ou un domaine WW et présente une affinité pour, en particulier, le récepteur de l'activine et/ou la molécule de transduction du signal intracellulaire de l'activine. L'invention concerne également un fragment peptidique ou un sel de ladite protéine, qui sont utiles pour déterminer une protéine de liaison capable de se lier à ladite protéine et de cribler un composé pouvant promouvoir ou inhiber la fixation de la protéine de liaison à ladite protéine, etc.
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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