Novel protein binding to osteoclastogenesis inhibitory...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257247

A novel protein binding to osteoclastogenesis inhibitory factor (OCIF) (OCIF- binding molecule; OBM). A DNA encoding the above protein; a protein having the amino acid sequence encoded by this DNA; a process for producing this protein by the genetic engineering technique; and medicinal compositions containing this protein. A method for screening a substance regulating the expression of the above protein, a substance inhibiting or modifying the biological activity of the above protein, or a receptor binding to the above protein and thus mediating its function with the use of the above protein and the DNA thereof; substances thus obtained; and medicinal compositions containing the substances thus obtained. An antibody against the above protein; a method for assaying the above protein by using the antibody; and drugs containing the antibody.

L'invention concerne une nouvelle protéine liant le facteur inhibant l'ostéoclastogénèse (OCIF) (molécule de liaison de l'OCIF: OBM). Elle concerne aussi un ADN codant ladite protéine; une protéine renfermant la séquence d'acides aminés codée par ledit ADN; une méthode permettant de produire ladite protéine par une technique de génie génétique; et des compositions médicamenteuses contenant ladite protéine. Elle concerne également une méthode permettant de cribler une substance régulant l'expression de ladite protéine, une substance inhibant ou modifiant l'activité biologique de ladite protéine, ou un récepteur fixant ladite protéine et servant ainsi de médiateur pour sa fonction au moyen de ladite protéine et de son ADN; des substances ainsi obtenues; et des compositions médicamenteuses contenant les substances ainsi obtenues. L'invention concerne enfin un anticorps dirigé contre ladite protéine; une méthode permettant de détecter ladite protéine au moyen dudit anticorps; et des médicaments contenant ledit anticorps.

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