C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 327/44 (2006.01) A61K 31/165 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2671632
The present invention provides new tyrphostin derivatives acting as substrate competitive protein tyrosine kinase (PTK) inhibitors and receptor tyrosine kinase (RTK) inhibitors, methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for preventions and treatments of PTK and RTK related disorders such as metabolic, fibrotic, and cell proliferative disorders, in particular psoriasis and cancer.
La présente invention porte sur de nouveaux dérivés de la tyrphostine agissant en tant qu'inhibiteurs de la protéine tyrosine kinase (PTK) compétitifs de substrat et inhibiteurs des récepteurs à activité tyrosine kinase (RTK), sur des procédés pour leur préparation, sur des compositions pharmaceutiques comprenant de tels composés, et sur des procédés d'utilisation de ces composés et compositions, notamment en tant qu'agents chimiothérapeutiques pour des préventions et des traitements de troubles associés à PTK et RTK, tels que des troubles métaboliques, fibrotiques et de prolifération cellulaire, en particulier le psoriasis et le cancer.
Ben-David Iris
Levitzki Alexander
Reuveni Hadas
Sasson Revital
Steiner Lilach
Novotyr Therapeutics Ltd.
Ridout & Maybee Llp
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