Novel protein kinase molecules and uses therefor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/00 (2006.01) A61N 1/365 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2342311

The invention provides isolated nucleic acids molecules, designated CSAPK nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CSAPK gene has been introduced or disrupted. The invention still further provides isolated CSAPK proteins, fusion proteins, antigenic peptides and anti-CSAPK antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules d'acide nucléique isolées dénommées molécules d'acide nucléique CSAPK, codant de nouvelles protéines kinases. L'invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression recombinés contenant des molécules d'acide nucléique CSAPK, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène CSAPK a été introduit ou dissocié. L'invention concerne en outre des protéines de CSAPK isolées, des protéines de fusion, des peptides antigéniques et des anticorps anti-CSAPK. L'invention concerne enfin des méthodes de diagnostic et de criblage et des méthodes thérapeutiques faisant intervenir les compositions selon l'invention.

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