Novel protein, process for producing the same and use thereof

Details Novel protein, process for producing the same and use thereof Novel protein, process for producing the same and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/711 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12N 9/99 (2006.01) C12P 21/08 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2424777

It is intended to provide a novel protein. More particularly, a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 or it salt; DNA encoding this protein; drugs containing the above protein or DNA; a method of screening a compound having an activity of promoting or inhibiting the peptidase activity of the above protein, etc. The above-described protein and the DNA encoding the same are usable as preventives and remedies for diseases such as cancer and neurodegenerative diseases. Cells capable of expressing the protein or its gene are useful as a material for screening a compound having an activity of promoting or inhibiting the peptidase activity of the above protein or its salt.

L'invention concerne une nouvelle protéine, contenant une séquence d'acide aminé, qui est la même ou sensiblement la même que la séquence d'acide aminé représentée par SEQ ID NO :1 ou son sel. La présente invention porte également sur un ADN codant cette protéine, des médicaments contenant ladite protéine ou ledit ADN, un procédé de criblage d'un composé activant ou inhibant l'activité peptidase de la protéine susmentionnée, etc. Ladite protéine et l'ADN codant celle-ci sont utiles dans les soins préventifs et thérapeutiques de maladies telles que le cancer et les maladies neurodégénératives. Des cellules pouvant exprimer cette protéine ou son gène s'avèrent utiles comme matériau de criblage d'un composé activant ou inhibant l'activité peptidase de la protéine susmentionnée ou de son sel.

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