C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2250425
The invention provides methods and compositions relating to a novel tumor necrosis factor receptor associated factor number six (TRAF6) polypeptide, which transcriptionally activates Nuclear Factor B. The invention provides isolated TRAF6 hybridization probes and primers capable of hybridizing with the disclosed TRAF6 gene, nucleic acids encoding the subject TRAF6 polypeptides, methods of making the subject TRAF6 polypeptides, and methods of using the subject compositions in diagnosis and drug screening.
L'invention porte sur des méthodes et compositions relatives à un nouveau polypeptide, le facteur N·6 associé au récepteur du facteur de nécrose des tumeurs (TRAF6) activant par transcription le facteur nucléaire ?B. L'invention porte sur des sondes et amorces d'hybridation du TRAF6 isolées capables de s'hybrider avec le gène du TRAF6, sur des acides nucléiques codant pour le polypeptide TRAF6, sur des méthodes d'obtention du polypeptide TRAF6, et sur des méthodes d'utilisation des susdites compositions à des fins de diagnostic et de criblage de médicaments.
Goeddel David V.
Xiong Jessie
Smart & Biggar
Tularik Inc.
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