C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2455225
The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More speficically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
L'invention concerne des nouveaux polynucléotides isolés et des polypeptides cibles de petites molécules codés par lesdits polynucléotides. L'invention concerne également des anticorps qui se lient de manière immunospécifique à un nouveau polypeptide cible de petite molécule ou à tout dérivé, variant, mutant ou fragment dudit polypeptide; ainsi que des procédés consistant à utiliser ledit polypeptide cible de petite molécule, ledit polynucléotide et ledit anticorps dans la détection et le traitement d'une gamme étendue d'états pathologiques. Plus particulièrement, l'invention concerne des méthodes d'utilisation de protéines exprimées par recombinaison et/ou de manière endogène dans divers procédés de criblage, à des fins d'identification d'anticorps thérapeutiques et de petites molécules associés à des maladies. L'invention concerne en outre des méthodes thérapeutiques, diagnostiques et de recherche pour le diagnostic, le traitement et la prévention de troubles impliquant un de ces nouveaux acides nucléiques humains et une de ces nouvelles protéines.
Agee Michele L.
Anderson David W.
Berghs Constance
Catterton Elina
Dipippo Vincent A.
Curagen Corporation
Na
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