Novel proteins and nucleic acids encoding same

Details Novel proteins and nucleic acids encoding same Novel proteins and nucleic acids encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/44 (2006.01) A61K 38/45 (2006.01) A61K 38/46 (2006.01) A61K 38/47 (2006.01) A61K 38/48 (2006.01) A61K 38/51 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 9/04 (2006.01) C12N 9/12 (2006.01) C12N 9/16 (2006.01) C12N 9/24 (2006.01) C12N 9/50 (2006.01) C12N 9/88 (2006.01) C12N 15/12

Patent

CA 2488539

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

La présente invention concerne de nouveaux polynucléotides isolés et polypeptides, ciblés par de petites molécules et codés par ces polynucléotides. Cette invention concerne également des anticorps se liant de façon immunospécifique à un nouveau polypeptide ciblé par de petites molécules ou tout dérivé, variant, mutant ou fragment de ce polypeptide, polynucléotide ou de cet anticorps ainsi que des méthodes dans lesquelles ce polypeptide ciblé par de petites molécules, ce polynucléotide et cet anticorps sont utilisés dans la détection et le traitement d'une large gamme d'états pathologiques. La présente invention concerne, plus spécifiquement, des méthodes d'utilisation de protéines exprimées de façon recombinante et/ou endogène dans diverses procédures de criblage à des fins d'identification d'anticorps thérapeutiques et de petites molécules thérapeutiques associés à des maladies. Cette invention concerne en outre des méthodes de recherche ainsi que des méthodes diagnostiques et thérapeutiques pour le diagnostic, le traitement et la prévention de troubles impliquant un de ces nouveaux acides nucléiques humains ou une de ces nouvelles protéines humaines.

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