C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/54 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2442574
The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
L'invention concerne des nouveaux polynucléotides isolés et des nouveaux polypeptides cibles de petites molécules codés par ces polynucléotides. L'invention concerne également des anticorps qui se fixent de manière immunospécifique à un nouveau polypeptide cible de petites molécules ou à tout autre dérivé, variant, mutant ou fragment dudit polypeptide, dudit polynucléotide ou dudit anticorps. En outre, l'invention concerne des méthodes dans lesquelles le polypeptide cible de petites molécules, le polynucléotide et l'anticorps sont utilisés pour la détection et le traitement d'une large gamme d'états pathologiques. Plus particulièrement, cette invention concerne des méthodes consistant à utiliser des protéines exprimées par recombinaison et/ou de manière endogène dans diverses procédures de criblage ayant pour but d'identifier des anticorps thérapeutiques et des petites molécules thérapeutiques associées à des maladies.
Anderson David W.
Burgess Catherine E.
Casman Stacie J.
Edinger Shlomit R.
Ellerman Karen
Curagen Corporation
Na
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