Novel proteins and nucleic acids encoding same

Details Novel proteins and nucleic acids encoding same Novel proteins and nucleic acids encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2481376

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

La présente invention a trait à des nouveaux polynucléotides isolés et des polypeptides cibles à petites molécules codés par les polynucléotides. L'invention a trait également à des anticorps qui se lient de manière immunospécifique à un polypeptide cible nouveau à petites molécules ou tout dérivé, variant, mutant ou fragment dudit polypeptide, polynucléotide ou anticorps, ainsi que des procédés dans lesquels le polypeptide cible à petites molécules, polynucléotide et anticorps sont utilisés dans la détection et le traitement d'une large gamme de conditions pathologiques. De manière plus spécifique, la présente invention a trait à des procédés d'utilisation de protéines exprimées de manière recombinante et/ou exprimées de manière endogène dans diverses procédures de criblage en vue de l'identification d'anticorps thérapeutiques et de petites molécules thérapeutiques associées à des maladies. L'invention a trait en outre à des procédés thérapeutiques, diagnostiques et de recherche pour le diagnostic, le traitement, et la prévention de troubles impliquant un quelconque desdits nouveaux acides nucléiques et protéines humains.

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