C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 31/711 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2511522
A compound inhibiting the expression of a protein having an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:4, SEQ ID NO:7 or SEQ ID O:10 or the expression of a gene of the protein, an antisense polynucleotide having a base sequence which is complementary or substantially complementary to the base sequence of DNA encoding the above protein or its peptide fragment or a part of the above base sequence, an antibody against the above protein or its peptide fragment, etc. are useful as preventives or remedies for cancer, etc., apoptosis promoters and so on.
La présente invention concerne un composé qui inhibe l'expression d'une protéine qui a une séquence d'acides aminés qui est identique ou sensiblement identique à la séquence d'acides aminés représentée par SEQ ID NO:1, SEQ ID NO:4, SEQ ID NO:7 ou SEQ ID NO:10, ou l'expression d'un gène de la protéine, un polynucléotide anti-sens ayant une séquence de bases qui est complémentaire ou sensiblement complémentaire à la séquence de bases d'ADN qui code pour la protéine mentionnée ci-dessus ou son fragment peptidique ou une partie de la séquence de bases mentionnée ci-dessus, un anticorps dirigé contre la protéine mentionnée ci-dessus ou son fragment peptidique, etc., qui sont utiles en tant qu'agents de prévention ou de traitement du cancer, etc., en tant qu'agents pour promouvoir l'apoptose etc.
Ishii Takafumi
Sato Shuji
Sunahara Eiji
Yamamoto Koji
Fetherstonhaugh & Co.
Takeda Pharmaceutical Company Limited
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