Novel proteins, gene encoding the same and method of...

Details Novel proteins, gene encoding the same and method of... Novel proteins, gene encoding the same and method of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) C07K 14/47 (2006.01) C07K 14/535 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2365397

A gene encoding an antigen recognized by G-CSF inductive antibody. Namely, a gene encoding: (a) a protein having the amino acid sequence represented by SEQ ID NO:2 in Sequence Listing; (b) a protein having an amino acid sequence derived from the amino acid sequence of SEQ ID NO:2 by deletion, substitution, addition or insertion of one or several amino acids and being capable of binding to an antibody having a granulocyte colony-stimulating factor inductive activity or a fragment thereof; or (c) a protein having an amino acid sequence with a homology of 50 % or more with the amino acid sequence of SEQ ID NO:2 and being capable of binding to an antibody having a granulocyte colony-stimulating factor inductive activity or a fragment thereof.

L'invention porte sur un gène codant un antigène reconnu par un anticorps inductif G-CSF. Ce gène code notamment: (a) une protéine ayant la séquence d'acides aminés représentée par le NO ID SEQ: 2 dans le listing de la séquence; (b) une protéine ayant une séquence d'acides aminés dérivée de la séquence NO 2, par délétion, substitution, addition ou insertion d'un ou plusieurs acides aminés et capable de lier à un anticorps ayant une activité induisant le facteur de stimulation d'une colonie de granulocytes ou un fragment de celui-ci; ou (c) une protéine ayant une séquence d'acides aminés présentant une homologie dans un rapport d'au moins 50 % avec la séquence d'acides aminés NO 2 et capable de lier à un anticorps ayant une activité induisant le facteur de stimulation d'une colonie de granulocytes ou un fragment de celui-ci.

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